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Anti-inflammatory and antioxidative effects of the buds from different species of Populus in human gingival fibroblast cells: Role of bioflavanones.

Identifieur interne : 000B27 ( Main/Exploration ); précédent : 000B26; suivant : 000B28

Anti-inflammatory and antioxidative effects of the buds from different species of Populus in human gingival fibroblast cells: Role of bioflavanones.

Auteurs : Loretta Pobłocka-Olech [Pologne] ; Iwona Inkielewicz-Stepniak [Pologne] ; Mirosława Krauze-Baranowska [Pologne]

Source :

RBID : pubmed:30668329

Descripteurs français

English descriptors

Abstract

BACKGROUND

Poplar leaf-buds (Populi gemmae) are used traditionally as anti-inflammatory agents to the treatment of skin injuries or cough. They differ in their diverse chemical composition and different types of activities, whose mechanisms are not fully recognized.

PURPOSE

Evaluation and comparison of anti-inflammatory activity of leaf-buds extracts from Populus nigra, P. × berolinensis and P. lasiocarpa and flavanones - pinocembrin and pinostrobin towards human gingival fibroblasts (HGF-1) pro-inflammatory stimulated by silver nanoparticles (AgNPs). Determination of antioxidant activity associated with anti-inflammatory properties by means of bioautographic TLC tests.

METHODS

Phytochemical analysis was performed by TLC and videodensitometry analysis. The extracts were standardized on the pinocembrin and pinostrobin content. Bioautography was performed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and riboflavin-light blue tetrazolium chloride (riboflavin-light-NBT) radicals to assess the extracts and both flavanones radical scavenging properties as well as potential inhibition of xanthine oxidase (XO) activity. The protective effects of poplar buds extract and flavanones - pinocembrin and pinostrobin on HGF-1 line exposured to AgNPs were investigated by analysis of interleukin 6 (IL-6) and interleukin IL-1β (IL-1β) level measured by ELISA kit. The messenger ribonucleic acid (mRNA) of both cytokines was determined by real-time quantitative PCR. The involvement of cyclooxygenase 2 protein (COX-2) was studied using Western blot analysis.

RESULTS

The presence of several flavanones and phenolic acids, which have radical scavenging properties, was revealed in all of the bud poplar extracts analyzed. Treatment with particular flavanones or extracts from buds of P. × berolinensis and P. nigra decreased the IL-6 and IL-1β release in HGF-1 cells and down-regulation of mRNA for both cytokines was observed. The COX-2 protein expression was demonstrated for pinocembrin and P. × berolinensis buds. These effects were not observed for buds from P. lasiocarpa not containing of flavonoids.

CONCLUSION

The potential protective role of pinocembrin and pinostrobin and extracts from buds P. nigra and P. × berolinensis against AgNPs induced inflammation and cytotoxicity in HGF-1 cells is disclosed. In addition, the antioxidant properties of poplar bud extracts have been demonstrated. P. × berolinensis buds showed the highest activity in both the in vitro model and in the bioautographic tests.


DOI: 10.1016/j.phymed.2018.08.015
PubMed: 30668329


Affiliations:

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Le document en format XML

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<term>Antioxidants (chemistry)</term>
<term>Antioxidants (pharmacology)</term>
<term>Cell Line (MeSH)</term>
<term>Cyclooxygenase 2 (metabolism)</term>
<term>Cytokines (genetics)</term>
<term>Cytokines (metabolism)</term>
<term>Drug Evaluation, Preclinical (methods)</term>
<term>Fibroblasts (drug effects)</term>
<term>Flavanones (pharmacology)</term>
<term>Gingiva (cytology)</term>
<term>Gingiva (drug effects)</term>
<term>Gingivitis (chemically induced)</term>
<term>Gingivitis (drug therapy)</term>
<term>Humans (MeSH)</term>
<term>Metal Nanoparticles (toxicity)</term>
<term>Plant Extracts (chemistry)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Plant Leaves (chemistry)</term>
<term>Populus (chemistry)</term>
<term>Silver (toxicity)</term>
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<term>Anti-inflammatoires (composition chimique)</term>
<term>Anti-inflammatoires (pharmacologie)</term>
<term>Antioxydants (composition chimique)</term>
<term>Antioxydants (pharmacologie)</term>
<term>Argent (toxicité)</term>
<term>Cyclooxygenase 2 (métabolisme)</term>
<term>Cytokines (génétique)</term>
<term>Cytokines (métabolisme)</term>
<term>Extraits de plantes (composition chimique)</term>
<term>Extraits de plantes (pharmacologie)</term>
<term>Feuilles de plante (composition chimique)</term>
<term>Fibroblastes (effets des médicaments et des substances chimiques)</term>
<term>Flavanones (pharmacologie)</term>
<term>Gencive (cytologie)</term>
<term>Gencive (effets des médicaments et des substances chimiques)</term>
<term>Gingivite (induit chimiquement)</term>
<term>Gingivite (traitement médicamenteux)</term>
<term>Humains (MeSH)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Nanoparticules métalliques (toxicité)</term>
<term>Populus (composition chimique)</term>
<term>Évaluation préclinique de médicament (méthodes)</term>
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<term>Anti-Inflammatory Agents</term>
<term>Antioxidants</term>
<term>Plant Extracts</term>
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<term>Gingivitis</term>
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<term>Plant Leaves</term>
<term>Populus</term>
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<term>Anti-inflammatoires</term>
<term>Antioxydants</term>
<term>Extraits de plantes</term>
<term>Feuilles de plante</term>
<term>Populus</term>
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<term>Anti-inflammatoires</term>
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<b>BACKGROUND</b>
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<p>Poplar leaf-buds (Populi gemmae) are used traditionally as anti-inflammatory agents to the treatment of skin injuries or cough. They differ in their diverse chemical composition and different types of activities, whose mechanisms are not fully recognized.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>PURPOSE</b>
</p>
<p>Evaluation and comparison of anti-inflammatory activity of leaf-buds extracts from Populus nigra, P. × berolinensis and P. lasiocarpa and flavanones - pinocembrin and pinostrobin towards human gingival fibroblasts (HGF-1) pro-inflammatory stimulated by silver nanoparticles (AgNPs). Determination of antioxidant activity associated with anti-inflammatory properties by means of bioautographic TLC tests.</p>
</div>
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<p>
<b>METHODS</b>
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<p>Phytochemical analysis was performed by TLC and videodensitometry analysis. The extracts were standardized on the pinocembrin and pinostrobin content. Bioautography was performed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and riboflavin-light blue tetrazolium chloride (riboflavin-light-NBT) radicals to assess the extracts and both flavanones radical scavenging properties as well as potential inhibition of xanthine oxidase (XO) activity. The protective effects of poplar buds extract and flavanones - pinocembrin and pinostrobin on HGF-1 line exposured to AgNPs were investigated by analysis of interleukin 6 (IL-6) and interleukin IL-1β (IL-1β) level measured by ELISA kit. The messenger ribonucleic acid (mRNA) of both cytokines was determined by real-time quantitative PCR. The involvement of cyclooxygenase 2 protein (COX-2) was studied using Western blot analysis.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>The presence of several flavanones and phenolic acids, which have radical scavenging properties, was revealed in all of the bud poplar extracts analyzed. Treatment with particular flavanones or extracts from buds of P. × berolinensis and P. nigra decreased the IL-6 and IL-1β release in HGF-1 cells and down-regulation of mRNA for both cytokines was observed. The COX-2 protein expression was demonstrated for pinocembrin and P. × berolinensis buds. These effects were not observed for buds from P. lasiocarpa not containing of flavonoids.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSION</b>
</p>
<p>The potential protective role of pinocembrin and pinostrobin and extracts from buds P. nigra and P. × berolinensis against AgNPs induced inflammation and cytotoxicity in HGF-1 cells is disclosed. In addition, the antioxidant properties of poplar bud extracts have been demonstrated. P. × berolinensis buds showed the highest activity in both the in vitro model and in the bioautographic tests.</p>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Poplar leaf-buds (Populi gemmae) are used traditionally as anti-inflammatory agents to the treatment of skin injuries or cough. They differ in their diverse chemical composition and different types of activities, whose mechanisms are not fully recognized.</AbstractText>
<AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Evaluation and comparison of anti-inflammatory activity of leaf-buds extracts from Populus nigra, P. × berolinensis and P. lasiocarpa and flavanones - pinocembrin and pinostrobin towards human gingival fibroblasts (HGF-1) pro-inflammatory stimulated by silver nanoparticles (AgNPs). Determination of antioxidant activity associated with anti-inflammatory properties by means of bioautographic TLC tests.</AbstractText>
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<Year>2018</Year>
<Month>06</Month>
<Day>28</Day>
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<li>Pologne</li>
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<name sortKey="Poblocka Olech, Loretta" sort="Poblocka Olech, Loretta" uniqKey="Poblocka Olech L" first="Loretta" last="Pobłocka-Olech">Loretta Pobłocka-Olech</name>
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<name sortKey="Inkielewicz Stepniak, Iwona" sort="Inkielewicz Stepniak, Iwona" uniqKey="Inkielewicz Stepniak I" first="Iwona" last="Inkielewicz-Stepniak">Iwona Inkielewicz-Stepniak</name>
<name sortKey="Krauze Baranowska, Miroslawa" sort="Krauze Baranowska, Miroslawa" uniqKey="Krauze Baranowska M" first="Mirosława" last="Krauze-Baranowska">Mirosława Krauze-Baranowska</name>
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